Brain mast cells link the immune system to anxiety-like behavior

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Brain mast cells link the immune system to anxiety-like behavior.

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Mast cells affect brain physiology and behavior. Katherine M. Nautiyal Mast cells are immune cells that are found in the brain. Behavioral and endocrine states increase the number and activation of brain mast cells, independent of the animal’s immune status. Activation causes the release of many neuro-active mediators into the brain parenchyma. However, the function or impact of mast cells in t...

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Mast cells are a heterogeneous population of granulocytic cells in the immune system. Mast cell granules contain numerous mediators, including neurotransmitters, cytokines, chemokines and lipid-derived factors. In addition to their well-known role in immune inflammation, the presence of mast cells in the meninges and perivascular space in the central nervous system points to their role in brain...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2008

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.0809479105